Rebif 22 mcg/0.5 ml Solution For Injection (Refrigerator)

Interferon Beta-1a 8.8 mcg

Interferon Beta-1a 22 mcg

Interferon Beta-1a 44 mcg

What Interferon Beta-1a is used for:

• • Interferon beta-1a is in a class of medications called immunomodulators and is used in adults with relapsing forms of multiple sclerosis to

• • Decrease flare-ups of symptoms (such as balance problems, numbness or weakness)

• • Help to slow disease worsening.

Do not take Interferon Beta-1a:

• • If you are allergic to interferon beta, human albumin, or any of the ingredients.

Warnings & Precautions:

• • Talk to your doctor or pharmacist before taking Interferon Beta-1a if you:

• • Have depression or suicide signs and symptoms

• • Have liver problems

• • Have bleeding problems or blood clots

• • Have thyroid problems

• • Are at risk for seizures

• • Are breastfeeding or plan to breastfeed

Possible Side Effects:

• • Skin reaction at the site of injection (itching, swelling, color change)

• • Abdominal pain

• • Influenza like symptoms (fever, cough, sore throat, headaches).

Other medicines and Interferon Beta-1a:

• • Tell your doctor or pharmacist about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

• • Interferon Beta-1a and other medicines may affect each other causing side effects.

• • Caution with medicinal products that have a narrow therapeutic index like digoxin, lithium, warfarin, and phenytoin.

How to take Interferon Beta-1a:

• • Adults above 18 years of age:

• • The usual dose is: 1 under the skin injected dose three times per week.

How To Use:

• • It is given by injection under the skin (subcutaneous injection) on the same 3 days a week, for example, Monday, Wednesday and Friday.

• • Take the syringe out of the refrigerator at least 30 minutes before you plan to use it until the temperature rises.

• • Do not heat or microwave the medicine.

• • Make sure the dose, 8.8 mcg, 22 mcg or 44 mcg, prescribed on the carton is the same dose that your healthcare provider has prescribed.

• • Remove the syringe from the plastic package. Keep the needle covered.

• • The liquid should be clear to slightly yellow. Do not use if the liquid is cloudy, discolored, or contains particles. Use a different syringe.

• • Your injections should be at least 48 hours apart. Take them the same time each day.

• • Inject exactly as your healthcare provider tells you.

• • Do not inject more than your healthcare provider tells you to.

• • Change (rotate) your injection site you choose with each injection.

• • This will help decrease the chance that you will have an injection site reaction.

• • Do not inject into an area of the body where the skin is irritated, reddened, bruised, infected or scarred in any way.

How to store Interferon Beta-1a:

• • Keep this medicine out of the sight and reach of children.

• • It should be stored refrigerated between 36°F to 46°F (2°C to 8°C). DO NOT FREEZE

• • The patient may remove it from the refrigerator and store it not above 25°C for one single period of up to 14 days.

• • Store the cartridge in the original package in order to protect from light.

• • Do not use beyond the expiration date printed on packages.

• • Each prefilled syringe and autoinjector is intended for a single dose.

• Any unused medicinal product or waste material should be disposed of in accordance with local requirements.