Tasigna 150mg Capsules

Tasigna is a medicine that contains the active substance nilotinib.

What Tasigna is used for:

• • Tasigna is used to treat a type of leukemia called Philadelphia chromosome-positive chronic myelogenous leukemia (Ph-positive CML).

• • CML is cancer of the blood that causes the body to produce too many abnormal white blood cells.

• • Tasigna is used in adults and children who have recently been told they have CML, or in patients who have no longer benefited from previous treatment (including imatinib).

• • It is also used for adults and children who have had serious side effects from previous treatment, and therefore cannot continue with it.

How Tasigna works:

• • In patients with CML, a change in the DNA (hereditary material) will trigger a signal that tells the body to produce abnormal white blood cells.

• • Tasigna blocks this signal and thus stops the production of these cells.

Check during treatment with Tasigna

Samples, including blood tests, will be taken regularly while the treatment is ongoing.

These tests will check:

• • The amount of blood cells (white blood cells, red blood cells and platelets ) in the body to see how well Tasigna is tolerated.

• • The function of the pancreas and liver to see how well Tasigna is tolerated.

• • The amount of electrolytes in the body (potassium, magnesium). These are important for the heart to function.

• • The amount of sugar and fat in the blood.

• • The heart rhythm will also be examined using a machine that measures electrical activity in the heart (a test called “ECG”).

• • Your doctor will regularly evaluate your treatment and decide whether you should continue taking Tasigna.

• • If you are told to stop using this medicine, your doctor will continue to monitor your disease.

• • You may be told to restart treatment with Tasigna, if your condition makes it necessary.

• Ask your doctor if you have any questions about how Tasigna works or why it has been prescribed for you or your child.

Ingredients:

The active substance is NILOTINIB.

• • Each 150 mg hard capsule contains 150 mg NILOTINIB (as hydrochloride monohydrate).

• Each 200 mg hard capsule contains 200 mg NILOTINIB (as hydrochloride monohydrate).