Xalkori 200mg Capsule

What Crizotinib is used for:

• • Crizotinib is an anticancer medicine used to treat adults with a type of lung cancer called non-small cell lung cancer, that presents with a specific rearrangement or defect in either a gene called anaplastic lymphoma kinase (ALK) or a gene called ROS1.

Do not use Crizotinib:

• • Do not use If you are allergic to crizotinib or any of the other ingredients of this medicine.

Possible side effects:

• • Stop using the product and seek immediate medical attention if you develop throat tightness or swelling of the eyes, face, lips or tongue, feel faint, or have difficulty breathing.

• • Stop using the product if you develop hives or itching of the face or body.

Other medicines and Crizotinib:

• • Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including herbal medicines and medicine obtained over the counter.

• • In particular, the following medicines may increase the risk of side effects with crizotinib:

• • Clarithromycin, telithromycin, erythromycin, antibiotics used to treat bacterial infections.

• • Ketoconazole, itraconazole, posaconazole, voriconazole, used to treat fungal infections.

• • Atazanavir, ritonavir, cobicistat, used to treat HIV infections/AIDS.

• • The following medicines may reduce the effectiveness of crizotinib:

• • Phenytoin, carbamazepine or phenobarbital, anti-epileptics used to treat seizures or fits.

• • Rifabutin, rifampicin, used to treat tuberculosis.

• • John’s wort (Hypericum perforatum), an herbal product used to treat depression.

• • Oral contraceptives

• • If you take it whilst using oral contraceptives, the oral contraceptives may be ineffective.

How to use Crizotinib:

• • Always take this medicine exactly as your doctor has told you.

• • Check with your doctor or pharmacist if you are not sure.

• • The recommended dose is one capsule of 250 mg taken orally twice daily (total amount 500 mg).

• • Take the capsule once in the morning and once in the evening.

• • Take the capsules at about the same time each day.

• • You can take the capsules with or without food always avoiding grapefruit.

• • Swallow the capsules whole and do not crush, dissolve or open the capsules

How to store Crizotinib:

• • Keep this medicine out of the sight and reach of children.

• • Do not use this medicine after the expiry date which is stated on the bottle or blister foil and carton after “EXP”.

• • The expiry date refers to the last day of that month.

• • This medicine does not require any special storage conditions.

• • Do not use any pack that is damaged or shows signs of tampering.

• Do not throw away any medicines via wastewater or household waste.